It can also lead to a loss of volume on the side of your face you sleep on. Cosmetically, you can usually resolve this issue with fillers, says Timothy R. Miller, MD. “Unlike wrinkles caused by facial expression most sleep wrinkles are not improved by Botox.” Instead, people need fillers like Juvederm, Restylane or Belotero, laser resurfacing, and even face-lifts to make a difference.

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