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Manchineel
The plant contains a number of toxins, and eating its fruits could possibly kill you and will most definitely blister your mouth and esophagus. The milky sap of the leaves and bark contains an irritating chemical called phorbol, which generates a strong allergic skin reaction. Raindrops falling through the tree can collect phorbol and burn a person standing underneath. Even touching the tree can cause the skin to blister. Native peoples have long used the sap to poison arrows, and it is thought that the explorer Juan Ponce de León possibly died from such a weapon during his second trip to Florida.
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